Joshua Sasine, MD

$100,000 CAREER DEVELOPMENT GRANT

Research Title: Eph/Ephrin Signaling Regulates Multiple Myeloma in the Bone Marrow Vascular Niche

University California Los Angeles

Multiple Myeloma is the second most common blood cancer. It arises out of plasma cells, whose normal function is to make antibodies to fight infections. Although in recent years the treatment has become more effective, it remains essentially incurable. One unique aspect of the disease is the close ties to the normal bone marrow cells, specifically the blood vessel cells. Without signals from these cells the cancer dies. We don’t know which signals are the most relevant; our experiments are designed to discover that. This could form the basis for new treatments designed to disrupt these pathways to benefit patients.

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